Introduction to Kinetics III (Biocatalysis)

Introduction to Kinetics III (Biocatalysis)

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Cyclic cascades

A cyclic cascade is an example of a complex sequence of reactions in which different forms of metabolically active enzymes are converted into one another.

The conversion involves various covalent modification and demodification reactions. The advantages of such interconvertible enzyme systems are

  • a larger number of allosteric stimuli (allostery),
  • flexible control processes,
  • sensitive reactions to changes in effector concentrations.

The enzymes that catalyze the modification and demodification of such a reaction are usually themselves allosterically regulated. A comparatively small change in the concentration of the effector can therefore lead to a large change in the concentration of an active, modified target enzyme.

One distinguishes

  • the monocyclic cascades
  • from the bicyclic cascades.

(cyclic cascades, control of the functional activity of glycogen phosphorylase)

Video: Enzymes Updated (August 2022).